This research examines how national culture influences the speed of COVID-19 spread in different countries. Three studies were conducted, and five national cultural dimensions were found to be significantly related to the speed of COVID-19 spread in the initial stages of the pandemic. These dimensions are power distance, uncertainty avoidance, humane orientation, in-group collectivism, and cultural tightness. The research found that COVID-19 spreads faster in countries with small power distance and strong uncertainty avoidance, low humane orientation and high in-group collectivism, and slower in countries with high cultural tightness.