A study assessed whether individuals express discriminatory attitudes in family and political settings across groups defined by COVID-19 vaccination status across 21 countries. The study found that vaccinated people express discriminatory attitudes towards unvaccinated individuals at a level as high as discriminatory attitudes commonly aimed at immigrant and minority populations. However, there was an absence of evidence that unvaccinated individuals display discriminatory attitudes towards vaccinated people. Discriminatory attitudes towards the unvaccinated were found in all countries except for Hungary and Romania and were more strongly expressed in cultures with stronger cooperative norms. The study suggests that contributors to the public good of epidemic control, such as vaccinated individuals, react negatively towards perceived "free-riders," such as unvaccinated individuals. The study also suggests that discriminatory attitudes, including support for the removal of fundamental rights, emerged despite appeals to moral obligations to increase COVID-19 vaccine uptake.